Chloride → [1-Benzyl-4-(4-fluorophenyl)piperidin-3-YL]methanol

HRID 802488Notes

Reaction equation

HRID 802488 reaction equation
[Al+3:2].[CH2:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[N:17]1[CH2:18][CH:19]([CH2:30][OH:31])[C:20]([c:23]2[cH:24][cH:25][c:26]([F:29])[cH:27][cH:28]2)=[CH:21][CH2:22]1.[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[Cl-:7].[Cl-:9].[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3].[Mg+2:8].[Na+:33].[OH-:32].[OH2:39]>>[CH2:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[N:17]1[CH2:18][CH:19]([CH2:30][OH:31])[CH:20]([c:23]2[cH:24][cH:25][c:26]([F:29])[cH:27][cH:28]2)[CH2:21][CH2:22]1

Participants

11

Reactant 10

HCID 312Chloride2×HCID 888Magnesium CationHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 9912522(+)-4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)-3-pyridinemethanol

Product 1

HCID 9926308[1-Benzyl-4-(4-fluorophenyl)piperidin-3-YL]methanol

Sources & evidence

ORD record
ord-d02b4f60818a44d088210bee412a53cc
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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