Dimethylformamide → 2-Tert-butyl-5-chloro-3-hydroxyisoindolin-1-one

HRID 803084Notes

Reaction equation

HRID 803084 reaction equation
[C:15]([Li:16])([CH3:17])([CH3:18])[CH3:19].[C:1]([CH3:2])([CH3:3])([CH3:4])[NH:5][C:6]([c:7]1[cH:8][cH:9][c:10]([Cl:13])[cH:11][cH:12]1)=[O:14].[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:20][CH2:21][CH2:22][CH2:23][CH3:24].[O:25]=[CH:26][N:27]([CH3:28])[CH3:29]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[N:5]1[C:6](=[O:14])[c:7]2[c:8]([cH:9][c:10]([Cl:13])[cH:11][cH:12]2)[CH:26]1[OH:25]

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8003PentaneHCID 8028TetrahydrofuranHCID 5873474-Chloro-N-(1,1-dimethylethyl)benzamideHCID 178418306HCID 178418306, compound

Product 1

HCID 251930612-Tert-butyl-5-chloro-3-hydroxyisoindolin-1-one

Sources & evidence

ORD record
ord-a748586b97024ba4916c3cf0892f0981
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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