1,2-Dichloroethane → 1-[4-[[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]carbamoyl]-5-methyl-3-oxo-2-phenylpyrazol-1-yl]propan-2-yl 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate

HRID 805157Notes

Reaction equation

HRID 805157 reaction equation
[C:41](=[O:42])([O:43][C:44]([CH3:45])([CH3:46])[CH3:47])[NH:48][CH2:49][C:50](=[O:51])[OH:52].[CH2:53]([Cl:54])[CH2:55][Cl:56].[CH3:57][N:58]([c:59]1[cH:60][cH:61][n:62][cH:63][cH:64]1)[CH3:65].[Cl:66][CH2:67][Cl:68].[F:1][c:2]1[cH:3][c:4]([NH:21][C:22](=[O:23])[c:24]2[c:25](=[O:40])[n:26](-[c:34]3[cH:35][cH:36][cH:37][cH:38][cH:39]3)[n:27]([CH2:30][CH:31]([CH3:32])[OH:33])[c:28]2[CH3:29])[cH:5][cH:6][c:7]1[O:8][c:9]1[cH:10][cH:11][n:12][c:13]2[cH:14][c:15]([O:19][CH3:20])[cH:16][cH:17][c:18]12>>[F:1][c:2]1[cH:3][c:4]([NH:21][C:22](=[O:23])[c:24]2[c:25](=[O:40])[n:26](-[c:34]3[cH:35][cH:36][cH:37][cH:38][cH:39]3)[n:27]([CH2:30][CH:31]([CH3:32])[O:33][C:50]([CH2:49][NH:48][C:41](=[O:42])[O:43][C:44]([CH3:45])([CH3:46])[CH3:47])=[O:51])[c:28]2[CH3:29])[cH:5][cH:6][c:7]1[O:8][c:9]1[cH:10][cH:11][n:12][c:13]2[cH:14][c:15]([O:19][CH3:20])[cH:16][cH:17][c:18]12

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 6344DichloromethaneHCID 142844-(Dimethylamino)pyridineHCID 78288N-(tert-butoxycarbonyl)glycineHCID 595983963-fluoro-4-(7-methoxyquinolin-4-yloxy)-phenyl-1-(2-hydroxypropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Product 1

HCID 666706851-[4-[[3-Fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]carbamoyl]-5-methyl-3-oxo-2-phenylpyrazol-1-yl]propan-2-yl 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate

Sources & evidence

ORD record
ord-b6886900a19640ef94af58f408361c32
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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