Hydrochloric Acid → 5-(6-(2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-1-carbonyl)pyrimidin-4-ylamino)-1,3-dihydro-spiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
Reaction equation
[B-:48]([F:49])([F:50])([F:51])[F:52].[CH:39]([N:40]([CH2:41][CH3:42])[CH:43]([CH3:44])[CH3:45])([CH3:46])[CH3:47].[ClH:1].[NH:30]1[CH2:31][CH2:32][c:33]2[cH:34][n:35][cH:36][cH:37][c:38]21.[O:2]=[C:3]1[NH:4][c:5]2[n:6][cH:7][cH:8][cH:9][c:10]2[C:11]12[CH2:12][c:13]1[cH:14][cH:15][c:16]([NH:20][c:21]3[cH:22][c:23]([C:27](=[O:28])[OH:29])[n:24][cH:25][n:26]3)[cH:17][c:18]1[CH2:19]2.[O:70]=[CH:71][N:72]([CH3:73])[CH3:74].[OH2:75].[n:53]1([O:54][C:55]([N:56]([CH3:57])[CH3:58])=[N+:59]([CH3:60])[CH3:61])[c:62]2[cH:63][cH:64][cH:65][cH:66][c:67]2[n:68][n:69]1>>[O:2]=[C:3]1[NH:4][c:5]2[n:6][cH:7][cH:8][cH:9][c:10]2[C:11]12[CH2:12][c:13]1[cH:14][cH:15][c:16]([NH:20][c:21]3[cH:22][c:23]([C:27](=[O:28])[N:30]4[CH2:31][CH2:32][c:33]5[cH:34][n:35][cH:36][cH:37][c:38]54)[n:24][cH:25][n:26]3)[cH:17][c:18]1[CH2:19]2Participants
9
Reactant 8
HCID 313Hydrochloric Acid
HCID 962Water
HCID 6228Dimethylformamide
HCID 26255Tetrafluoroborate
HCID 81531Diisopropylethylamine
HCID 130500O-benzotriazol-1-yl-tetramethyluronium
HCID 124909791H,2H,3H-pyrrolo(3,2-c)pyridine
HCID 581174936-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]pyrimidine-4-carboxylic acidProduct 1
Sources & evidence
- ORD record
- ord-d67dd021f2794704b5832ff5b2d555be
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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