Acetate → 5-Carbomethoxy-8-(3-pyridyl)-oct-7-enenitrile

HRID 805441Notes

Reaction equation

HRID 805441 reaction equation
[Br:14][c:15]1[cH:16][n:17][cH:18][cH:19][cH:20]1.[C:1](=[O:2])([O:3][CH3:4])[CH:5]([CH2:6][CH2:7][CH2:8][C:9]#[N:10])[CH2:11][CH:12]=[CH2:13].[C:53]([O-:54])(=[O:55])[CH3:56].[C:58]([O-:59])(=[O:60])[CH3:61].[CH3:43][C:44]#[N:45].[CH3:46][CH2:47][N:48]([CH2:49][CH3:50])[CH2:51][CH3:52].[Pd+2:57].[c:21]1([CH3:22])[cH:23][cH:24][cH:25][cH:26][c:27]1[P:28]([c:29]1[cH:30][cH:31][cH:32][cH:33][c:34]1[CH3:35])[c:36]1[cH:37][cH:38][cH:39][cH:40][c:41]1[CH3:42]>>[C:1](=[O:2])([O:3][CH3:4])[CH:5]([CH2:6][CH2:7][CH2:8][C:9]#[N:10])[CH2:11][CH:12]=[CH:13][c:15]1[cH:16][n:17][cH:18][cH:19][cH:20]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 6342AcetonitrileHCID 8471TriethylamineHCID 122863-BromopyridineHCID 80271Tri-o-tolylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 149867035-Carbomethoxy-oct-7-enenitrile

Product 1

HCID 543965835-Carbomethoxy-8-(3-pyridyl)-oct-7-enenitrile

Sources & evidence

ORD record
ord-8340b667938446779f3ee603bc61aef0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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