Water → 3-(4-Chloro-phenyl)-6-[4-(4-pyrrolidin-1-ylmethyl-phenyl)-but-1-ynyl]-pyridazin

HRID 805462Notes

Reaction equation

HRID 805462 reaction equation
[CH2:22]([CH2:23][C:24]#[CH:25])[c:26]1[cH:27][cH:28][c:29]([CH2:30][N:31]2[CH2:32][CH2:33][CH2:34][CH2:35]2)[cH:36][cH:37]1.[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[Cl:8][c:9]1[n:10][n:11][c:12](-[c:15]2[cH:16][cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[cH:13][cH:14]1.[Cu:44][I:45].[O:39]=[CH:40][N:41]([CH3:42])[CH3:43].[OH2:38]>>[c:9]1([C:25]#[C:24][CH2:23][CH2:22][c:26]2[cH:27][cH:28][c:29]([CH2:30][N:31]3[CH2:32][CH2:33][CH2:34][CH2:35]3)[cH:36][cH:37]2)[n:10][n:11][c:12](-[c:15]2[cH:16][cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[cH:13][cH:14]1

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 122575023-Chloro-6-(4-chlorophenyl)pyridazineHCID 859698431-(4-But-3-ynyl-benzyl)-pyrrolidine

Product 1

HCID 100924723-(4-Chloro-phenyl)-6-[4-(4-pyrrolidin-1-ylmethyl-phenyl)-but-1-ynyl]-pyridazin

Sources & evidence

ORD record
ord-31aa35d977bf470b8b6033fdce1c3724
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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