Hydrochloric Acid → HCID 178448364, compound

HRID 80597Notes

Reaction equation

HRID 80597 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]([C@H:11]([NH:15][C:16]([N:18]2[C:24](=[O:25])[C@H:23]([CH2:26][C:27]3[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:28]=3[O:34][CH3:35])[CH2:22][NH:21][C:20](=[N:36][O:37][CH2:38][CH3:39])[CH2:19]2)=[O:17])[CH2:12][CH2:13][CH3:14])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(#N)C.[ClH:43]>C(OCC)(=O)C>[ClH:33].[ClH:43].[NH2:1][C:2]1[CH:10]=[C:9]([C@H:11]([NH:15][C:16]([N:18]2[C:24](=[O:25])[C@H:23]([CH2:26][C:27]3[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:28]=3[O:34][CH3:35])[CH2:22][NH:21][C:20](=[N:36][O:37][CH2:38][CH3:39])[CH2:19]2)=[O:17])[CH2:12][CH2:13][CH3:14])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6342AcetonitrileHCID 178448361HCID 178448361, compound

Product 1

HCID 178448364HCID 178448364, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To the compound 102 (1.10 g) in an acetonitrile (44 ml) solution, a 4M hydrochloric acid in ethyl acetate solution (1.5 ml) was added, and the mixture was stirred at room temperature for 5 hours. The precipitated crystals were collected by filtration to obtain the title compound (1.03 g) as a colorless crystal.

Workup

  1. filtrationThe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-f2ceab900edd4098b6e1b4a99b5b0ffd
Source dataset
uspto-grants-2014_09
Patent number
US08846660B2

Reaction notes

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