Hydrochloric Acid → 5-Amino-4-methyl-2-(1-methyl-piperidin-4-yl)-6-nitro-isoindole-1,3-dione

HRID 806700Notes

Reaction equation

HRID 806700 reaction equation
[CH3:19][CH2:20][N:21]=[C:22]=[N:23][CH2:24][CH2:25][CH2:26][N:27]([CH3:28])[CH3:29].[CH3:1][O:2][C:3]([c:4]1[c:5]([C:6](=[O:7])[OH:8])[cH:9][c:10]([N+:15](=[O:16])[O-:17])[c:11]([NH2:14])[c:12]1[CH3:13])=[O:18].[CH3:51][CH2:52][N:53]([CH2:54][CH3:55])[CH2:56][CH3:57].[ClH:30].[ClH:41].[ClH:42].[NH2:43][CH:44]1[CH2:45][CH2:46][N:47]([CH3:50])[CH2:48][CH2:49]1.[OH:31][n:32]1[c:33]2[c:34]([cH:35][cH:36][cH:37][cH:38]2)[n:39][n:40]1>>[C:3]1(=[O:18])[c:4]2[c:5]([cH:9][c:10]([N+:15](=[O:16])[O-:17])[c:11]([NH2:14])[c:12]2[CH3:13])[C:6](=[O:8])[N:43]1[CH:44]1[CH2:45][CH2:46][N:47]([CH3:50])[CH2:48][CH2:49]1

Participants

7

Reactant 6

HCID 313Hydrochloric Acid3×HCID 8471TriethylamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 27375314-Amino-1-methylpiperidineHCID 597616804-Amino-2-(methoxycarbonyl)-3-methyl-5-nitrobenzoic acid

Product 1

HCID 597618595-Amino-4-methyl-2-(1-methyl-piperidin-4-yl)-6-nitro-isoindole-1,3-dione

Sources & evidence

ORD record
ord-2002f61eacfd49d8b83fe3f027291c36
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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