Nitrogen → Hydrochloric Acid

HRID 806714Notes

Reaction equation

HRID 806714 reaction equation
[C:20](#[CH:21])[c:22]1[cH:23][c:24]([NH2:25])[cH:26][cH:27][cH:28]1.[CH:31]([OH:32])([CH3:33])[CH3:34].[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]2[cH:7][c:8]([O:16][CH2:17][CH2:18][Cl:19])[c:9]([O:12][CH2:13][CH2:14][Cl:15])[cH:10][c:11]12.[N:29]#[N:30]>>[ClH:1].[c:2]1([NH:25][c:24]2[cH:23][c:22]([C:20]#[CH:21])[cH:28][cH:27][cH:26]2)[n:3][cH:4][n:5][c:6]2[cH:7][c:8]([O:16][CH2:17][CH2:18][Cl:19])[c:9]([O:12][CH2:13][CH2:14][Cl:15])[cH:10][c:11]12

Participants

6

Reactant 4

HCID 947NitrogenHCID 3776IsopropanolHCID 104682Benzenamine, 3-ethynyl-HCID 189250384-Chloro-6,7-bis(2-chloroethoxy)quinazoline

Product 2

HCID 313Hydrochloric AcidHCID 16045653Erlotinib iMpurity

Sources & evidence

ORD record
ord-336cb2329b4d46d2b7577cf89578bd3e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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