Bicarbonate Ion → 2-Chloro-3-(2,2,2-trifluoroethoxy)pyridine

HRID 807319Notes

Reaction equation

HRID 807319 reaction equation
[C:29](=[O:30])([OH:31])[O-:32].[N:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28].[NH2:1][c:2]1[c:3]([Cl:8])[n:4][cH:5][cH:6][cH:7]1.[Na+:33].[OH:15][C:16]([C:17]([F:18])([F:19])[F:20])=[O:21].[OH:9][CH2:10][C:11]([F:12])([F:13])[F:14]>>[c:2]1([O:9][CH2:10][C:11]([F:12])([F:13])[F:14])[c:3]([Cl:8])[n:4][cH:5][cH:6][cH:7]1

Participants

7

Reactant 6

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 64092,2,2-TrifluoroethanolHCID 6422Trifluoroacetic acidHCID 10906Tert-Butyl nitriteHCID 805282-Chloro-3-pyridylamine

Product 1

HCID 120567282-Chloro-3-(2,2,2-trifluoroethoxy)pyridine

Sources & evidence

ORD record
ord-a4eedd9431fb44ab91bf83331987cc08
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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