1,2-Dichloroethane → N-(6-(5-cyanopyrazin-2-ylamino)-4-(1-boc-piperidin-4-ylmethylamino)pyridin-3-yl)-2-(dimethylamino)acetamide

HRID 807435Notes

Reaction equation

HRID 807435 reaction equation
[CH2:27]([Cl:28])[CH2:29][Cl:30].[CH3:10][N:11]([CH3:12])[CH2:13][C:14]([OH:15])=[O:16].[CH:1]([N:2]([CH:3]([CH3:4])[CH3:5])[CH2:6][CH3:7])([CH3:8])[CH3:9].[NH2:31][c:32]1[c:33]([NH:47][CH2:48][CH:49]2[CH2:50][CH2:51][N:52]([C:55](=[O:56])[O:57][C:58]([CH3:59])([CH3:60])[CH3:61])[CH2:53][CH2:54]2)[cH:34][c:35]([NH:38][c:39]2[n:40][cH:41][c:42]([C:45]#[N:46])[n:43][cH:44]2)[n:36][cH:37]1.[O:62]=[CH:63][N:64]([CH3:65])[CH3:66].[OH:17][n:18]1[c:19]2[c:20]([cH:21][cH:22][cH:23][cH:24]2)[n:25][n:26]1>>[CH3:10][N:11]([CH3:12])[CH2:13][C:14](=[O:16])[NH:31][c:32]1[c:33]([NH:47][CH2:48][CH:49]2[CH2:50][CH2:51][N:52]([C:55](=[O:56])[O:57][C:58]([CH3:59])([CH3:60])[CH3:61])[CH2:53][CH2:54]2)[cH:34][c:35]([NH:38][c:39]2[n:40][cH:41][c:42]([C:45]#[N:46])[n:43][cH:44]2)[n:36][cH:37]1

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 673N,N-DimethylglycineHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 59613544Tert-butyl 4-((5-amino-2-(5-cyanopyrazin-2-ylamino)pyridin-4-ylamino)methyl)piperidine-1-carboxylate

Product 1

HCID 66746296N-(6-(5-cyanopyrazin-2-ylamino)-4-(1-boc-piperidin-4-ylmethylamino)pyridin-3-yl)-2-(dimethylamino)acetamide

Sources & evidence

ORD record
ord-35ce8d2fd4194d969755243820887559
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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