Water → 6-{3-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl)-propyl]-phenoxy}-nicotinic acid methyl ester

HRID 807537Notes

Reaction equation

HRID 807537 reaction equation
[CH3:28][O:29][C:30]([c:31]1[cH:32][n:33][c:34]([Cl:37])[cH:35][cH:36]1)=[O:38].[CH3:39][CH2:40][N:41]([CH2:42][CH3:43])[CH2:44][CH3:45].[Cl:1][c:2]1[c:3]([CH:9]([C:10]([C:11]([F:12])([F:13])[F:14])([OH:15])[c:16]2[cH:17][cH:18][c:19]3[c:20]([n:21]([CH3:25])[c:22](=[O:24])[o:23]3)[cH:26]2)[CH3:27])[cH:4][cH:5][c:6]([OH:8])[cH:7]1.[N:46]12[CH2:47][CH2:48][N:49]([CH2:50][CH2:51]1)[CH2:52][CH2:53]2.[O:54]=[CH:55][N:56]([CH3:57])[CH3:58].[OH2:59]>>[Cl:1][c:2]1[c:3]([CH:9]([C:10]([C:11]([F:12])([F:13])[F:14])([OH:15])[c:16]2[cH:17][cH:18][c:19]3[c:20]([n:21]([CH3:25])[c:22](=[O:24])[o:23]3)[cH:26]2)[CH3:27])[cH:4][cH:5][c:6]([O:8][c:34]2[n:33][cH:32][c:31]([C:30]([O:29][CH3:28])=[O:38])[cH:36][cH:35]2)[cH:7]1

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 8471TriethylamineHCID 9237DabcoHCID 254249Methyl 6-chloropyridine-3-carboxylateHCID 666969865-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-3-methyl-3H-benzooxazol-2-one

Product 1

HCID 666970486-{3-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl)-propyl]-phenoxy}-nicotinic acid methyl ester

Sources & evidence

ORD record
ord-bb573d947cec43eba2b7b5b6316906d4
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…