Piperidine → 6-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]-4-methyl-2-(4-methylpiperidin-1-yl)quinoline

HRID 808101Notes

Reaction equation

HRID 808101 reaction equation
[CH2:35]1[CH2:36][CH2:37][NH:38][CH2:39][CH2:40]1.[CH2:47]1[O:48][CH2:49][CH2:50][O:51][CH2:52]1.[CH3:41][CH2:42][O:43][C:44]([CH3:45])=[O:46].[Cl:20][c:21]1[cH:22][cH:23][c:24](-[c:27]2[cH:28][cH:29][c:30]([C:33]#[CH:34])[n:31][cH:32]2)[cH:25][cH:26]1.[Cu:53][I:54].[I:1][c:2]1[cH:3][c:4]2[c:5]([CH3:19])[cH:6][c:7]([N:12]3[CH2:13][CH2:14][CH:15]([CH3:18])[CH2:16][CH2:17]3)[n:8][c:9]2[cH:10][cH:11]1>>[c:2]1([C:34]#[C:33][c:30]2[cH:29][cH:28][c:27](-[c:24]3[cH:23][cH:22][c:21]([Cl:20])[cH:26][cH:25]3)[cH:32][n:31]2)[cH:3][c:4]2[c:5]([CH3:19])[cH:6][c:7]([N:12]3[CH2:13][CH2:14][CH:15]([CH3:18])[CH2:16][CH2:17]3)[n:8][c:9]2[cH:10][cH:11]1

Participants

7

Reactant 6

HCID 8082PiperidineHCID 8857Ethyl AcetateHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 312751,4-DioxaneHCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 690607816-Iodo-4-methyl-2-(4-methylpiperidin-1-yl)quinoline

Product 1

HCID 576433036-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]-4-methyl-2-(4-methylpiperidin-1-yl)quinoline

Sources & evidence

ORD record
ord-49a46ff6e3a943bca40dadb7f7b840c7
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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