Dichloromethane → Trifluoromethanesulfonic acid

HRID 808647Notes

Reaction equation

HRID 808647 reaction equation
[CH3:42][CH2:43][N:44]([CH2:45][CH3:46])[CH2:47][CH3:48].[Cl:49][CH2:50][Cl:51].[F:16][c:17]1[c:18](-[c:24]2[n:25][c:26]([NH:35][c:36]3[n:37][nH:38][c:39]([CH3:41])[cH:40]3)[cH:27][c:28]3[cH:29][c:30]([OH:34])[cH:31][cH:32][c:33]23)[cH:19][cH:20][c:21]([F:23])[cH:22]1.[F:1][C:2]([F:3])([F:4])[S:5](=[O:6])(=[O:7])[O:8][S:9]([C:10]([F:11])([F:12])[F:13])(=[O:14])=[O:15]>>[F:16][c:17]1[c:18](-[c:24]2[n:25][c:26]([NH:35][c:36]3[n:37][nH:38][c:39]([CH3:41])[cH:40]3)[cH:27][c:28]3[cH:29][c:30]([OH:34])[cH:31][cH:32][c:33]23)[cH:19][cH:20][c:21]([F:23])[cH:22]1.[F:1][C:2]([F:3])([F:4])[S:5](=[O:6])(=[O:7])[OH:8]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 67749Trifluoromethanesulfonic anhydrideHCID 1360555241-(2,4-difluoro-phenyl)-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol

Product 2

HCID 62406Trifluoromethanesulfonic acidHCID 1360555241-(2,4-difluoro-phenyl)-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol

Sources & evidence

ORD record
ord-f908fd42e1014c6185466132c2ae5fd4
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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