N-methyl-2-pyrrolidone → 2-(5-bromo-2-chloro-pyrimidin-4-ylamino)-3-fluoro-N-methyl-benzamide

HRID 808890Notes

Reaction equation

HRID 808890 reaction equation
[Br:13][c:14]1[c:15]([Cl:21])[n:16][c:17]([Cl:20])[n:18][cH:19]1.[CH3:31][N:32]1[CH2:33][CH2:34][CH2:35][C:36]1=[O:37].[CH:22]([N:23]([CH2:24][CH3:25])[CH:26]([CH3:27])[CH3:28])([CH3:29])[CH3:30].[NH2:1][c:2]1[c:3]([C:4](=[O:5])[NH:6][CH3:7])[cH:8][cH:9][cH:10][c:11]1[F:12]>>[NH:1]([c:2]1[c:3]([C:4](=[O:5])[NH:6][CH3:7])[cH:8][cH:9][cH:10][c:11]1[F:12])[c:15]1[c:14]([Br:13])[cH:19][n:18][c:17]([Cl:20])[n:16]1

Participants

5

Reactant 4

HCID 13387N-methyl-2-pyrrolidoneHCID 81531DiisopropylethylamineHCID 2899735-Bromo-2,4-dichloropyrimidineHCID 272815042-Amino-3-fluoro-n-methylbenzamide

Product 1

HCID 866338872-(5-bromo-2-chloro-pyrimidin-4-ylamino)-3-fluoro-N-methyl-benzamide

Sources & evidence

ORD record
ord-f1cabdf6f6e846f7b88db76331342935
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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