Water → N-[2-{5-[(1,1-dioxidothiomorpholino)methyl]-4,5-dihydro-1,3-thiazol-2-yl}-5-(2-methoxyethoxy)-1H-indol-7-yl]pyridine-2-sulfonamide

HRID 809674Notes

Reaction equation

HRID 809674 reaction equation
[CH2:36]([c:38]1[cH:39][cH:40][cH:41][cH:42][cH:48]1)[S:43][CH:44]([CH2:45][NH:46][C:47](=[O:37])[c:49]1[nH:50][c:51]2[c:52]([NH:63][S:64](=[O:65])(=[O:66])[c:67]3[n:68][cH:69][cH:70][cH:71][cH:72]3)[cH:53][c:54]([O:58][CH2:59][CH2:60][O:61][CH3:62])[cH:55][c:56]2[cH:57]1)[CH2:73][N:74]1[CH2:75][CH2:76][S:77](=[O:80])(=[O:81])[CH2:78][CH2:79]1.[Cl:90][CH2:91][Cl:92].[F:1][C:2]([S:3]([O:4][S:5]([C:6]([F:7])([F:8])[F:9])(=[O:10])=[O:11])(=[O:12])=[O:13])([F:14])[F:15].[OH2:93].[c:16]1([P:17](=[O:18])([c:19]2[cH:20][cH:21][cH:22][cH:23][cH:24]2)[c:25]2[cH:26][cH:27][cH:28][cH:29][cH:30]2)[cH:31][cH:32][cH:33][cH:34][cH:35]1.[c:82]1([S:83][CH3:84])[cH:85][cH:86][cH:87][cH:88][cH:89]1>>[S:43]1[CH:44]([CH2:73][N:74]2[CH2:75][CH2:76][S:77](=[O:80])(=[O:81])[CH2:78][CH2:79]2)[CH2:45][N:46]=[C:47]1[c:49]1[nH:50][c:51]2[c:52]([NH:63][S:64](=[O:65])(=[O:66])[c:67]3[n:68][cH:69][cH:70][cH:71][cH:72]3)[cH:53][c:54]([O:58][CH2:59][CH2:60][O:61][CH3:62])[cH:55][c:56]2[cH:57]1

Participants

7

Reactant 6

HCID 962WaterHCID 6344DichloromethaneHCID 7520ThioanisoleHCID 13097Triphenylphosphine OxideHCID 67749Trifluoromethanesulfonic anhydrideHCID 59303523N-[2-(benzylthio)-3-(1,1-dioxidothiomorpholino)propyl]-5-(2-methoxyethoxy)-7-[(pyridin-2-ylsulfonyl)amino]-1H-indole-2-carboxamide

Product 1

HCID 67487668N-[2-{5-[(1,1-dioxidothiomorpholino)methyl]-4,5-dihydro-1,3-thiazol-2-yl}-5-(2-methoxyethoxy)-1H-indol-7-yl]pyridine-2-sulfonamide

Sources & evidence

ORD record
ord-9a157a37b34144a5a97ec3b74551b450
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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