Ammonium → Methyl 2-hydroxy-3-cyclopropyl-3-methylbutanoate

HRID 810361Notes

Reaction equation

HRID 810361 reaction equation
[CH2:26]1[CH2:29][CH2:28][CH2:27][O:30]1.[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH3:31][CH2:32][O:33][C:34]([CH3:35])=[O:36].[CH:13]1([C:16]([CH2:17][C:18](=[O:19])[O:20][CH3:21])([CH3:22])[CH3:23])[CH2:14][CH2:15]1.[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Cl-:24].[NH4+:25]>>[CH:13]1([C:16]([CH:17]([C:18](=[O:19])[O:20][CH3:21])[OH:30])([CH3:22])[CH3:23])[CH2:14][CH2:15]1

Participants

8

Reactant 7

HCID 223AmmoniumHCID 312ChlorideHCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 18625543Methyl 3-cyclopropyl-3-methylbutanoateHCID 178418339Butyllithium

Product 1

HCID 18625550Methyl 2-hydroxy-3-cyclopropyl-3-methylbutanoate

Sources & evidence

ORD record
ord-56e1f25a2fb74713adce8e8b6aad2175
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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