Chloride → methyl 6-bromo-1-cyclobutyl-1H-indole-4-carboxylate

HRID 811331Notes

Reaction equation

HRID 811331 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:11](=[O:12])[O:13][CH3:14])[c:5]2[cH:6][cH:7][nH:8][c:9]2[cH:10]1.[C:16]([CH2:17][P+:18]([CH3:19])([CH3:20])[CH3:21])#[N:22].[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:35][CH2:36][O:37][C:38]([CH3:39])=[O:40].[CH3:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46].[CH:23]1([OH:27])[CH2:24][CH2:25][CH2:26]1.[Cl-:15].[H-:28].[Na+:29]>>[Br:1][c:2]1[cH:3][c:4]([C:11](=[O:12])[O:13][CH3:14])[c:5]2[cH:6][cH:7][n:8]([CH:23]3[CH2:24][CH2:25][CH2:26]3)[c:9]2[cH:10]1

Participants

10

Reactant 9

HCID 312ChlorideHCID 923Sodium ionHCID 8028TetrahydrofuranHCID 8058HexaneHCID 8857Ethyl AcetateHCID 76218CyclobutanolHCID 166653HydrideHCID 10514345Cyanomethyl(trimethyl)phosphaniumHCID 13770009methyl 6-bromo-1H-indole-4-carboxylate

Product 1

HCID 67469195methyl 6-bromo-1-cyclobutyl-1H-indole-4-carboxylate

Sources & evidence

ORD record
ord-3347b2d15e8d4af3845adb4379f3ea12
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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