Hydrochloric Acid → 3-Butyl-3-(3-hydroxyphenyl)-1-methylazepan-2-one

HRID 812378Notes

Reaction equation

HRID 812378 reaction equation
[CH:17]([N-:18][CH:19]([CH3:20])[CH3:21])([CH3:22])[CH3:23].[ClH:25].[Li+:24].[O:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1.[OH:1][c:2]1[cH:3][c:4]([CH:8]2[C:9](=[O:16])[N:10]([CH3:15])[CH2:11][CH2:12][CH2:13][CH2:14]2)[cH:5][cH:6][cH:7]1>>[OH:1][c:2]1[cH:3][c:4]([C:8]2([CH2:27][CH2:28][CH2:29][CH3:30])[C:9](=[O:16])[N:10]([CH3:15])[CH2:11][CH2:12][CH2:13][CH2:14]2)[cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 5062348DiisopropylamideHCID 11746121hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one

Product 1

HCID 203447883-Butyl-3-(3-hydroxyphenyl)-1-methylazepan-2-one

Sources & evidence

ORD record
ord-5197967f4c5545d989a664c7092dc7f2
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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