Hydrochloric Acid → (3aRS, 7aRS)-2-benzyl-7,7-diphenyl-4-perhydroisoindolone

HRID 812564Notes

Reaction equation

HRID 812564 reaction equation
[Br:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[Cl:32][CH2:33][Cl:34].[ClH:9].[c:10]1([C:16]2([c:26]3[cH:27][cH:28][cH:29][cH:30][cH:31]3)[CH2:17][CH2:18][C:19](=[O:25])[CH:20]3[CH2:21][NH:22][CH2:23][CH:24]23)[cH:11][cH:12][cH:13][cH:14][cH:15]1>>[CH2:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[N:22]1[CH2:21][CH:20]2[C:19](=[O:25])[CH2:18][CH2:17][C:16]([c:10]3[cH:11][cH:12][cH:13][cH:14][cH:15]3)([c:26]3[cH:27][cH:28][cH:29][cH:30][cH:31]3)[CH:24]2[CH2:23]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 7498Benzyl BromideHCID 8471TriethylamineHCID 21264544(3aRS,7aRS)-7,7-Diphenylperhydro-4-isoindolone

Product 1

HCID 19384608(3aRS, 7aRS)-2-benzyl-7,7-diphenyl-4-perhydroisoindolone

Sources & evidence

ORD record
ord-96b002c14cdf40229f2e50127dcb05fc
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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