Hydrochloric Acid → 6-(1-Acetylpiperidin-4-yloxy)-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline

HRID 813115Notes

Reaction equation

HRID 813115 reaction equation
[CH2:44]([Cl:45])[Cl:46].[CH3:1][C:2]([Cl:3])=[O:4].[CH:35]([N:36]([CH:37]([CH3:38])[CH3:39])[CH2:40][CH3:41])([CH3:42])[CH3:43].[ClH:5].[ClH:6].[NH:7]1[CH2:8][CH2:9][CH:10]([O:13][c:14]2[cH:15][c:16]3[c:17]([NH:26][c:27]4[c:28]([F:34])[c:29]([Cl:33])[cH:30][cH:31][cH:32]4)[n:18][cH:19][n:20][c:21]3[cH:22][c:23]2[O:24][CH3:25])[CH2:11][CH2:12]1>>[CH3:1][C:2](=[O:4])[N:7]1[CH2:8][CH2:9][CH:10]([O:13][c:14]2[cH:15][c:16]3[c:17]([NH:26][c:27]4[c:28]([F:34])[c:29]([Cl:33])[cH:30][cH:31][cH:32]4)[n:18][cH:19][n:20][c:21]3[cH:22][c:23]2[O:24][CH3:25])[CH2:11][CH2:12]1

Participants

6

Reactant 5

HCID 313Hydrochloric Acid2×HCID 6344DichloromethaneHCID 6367Acetyl chlorideHCID 81531DiisopropylethylamineHCID 10408840N-(3-chloro-2-fluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazolin-4-amine

Product 1

HCID 104336176-(1-Acetylpiperidin-4-yloxy)-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline

Sources & evidence

ORD record
ord-9e00eee30d9d4530891d940353197406
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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