Dichloromethane → Tert-butyl 4-fluoro-4-((tosyloxy)methyl)piperidine-1-carboxylate

HRID 813170Notes

Reaction equation

HRID 813170 reaction equation
[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[CH3:35][N:36]([c:37]1[cH:38][cH:39][n:40][cH:41][cH:42]1)[CH3:43].[Cl:44][CH2:45][Cl:46].[F:12][C:13]1([CH2:26][OH:27])[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]1.[c:1]1([CH3:11])[cH:2][cH:3][c:4]([S:7](=[O:8])(=[O:9])[Cl:10])[cH:5][cH:6]1>>[c:1]1([CH3:11])[cH:2][cH:3][c:4]([S:7](=[O:8])(=[O:9])[O:27][CH2:26][C:13]2([F:12])[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]2)[cH:5][cH:6]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 73974-Toluenesulfonyl chlorideHCID 8471TriethylamineHCID 142844-(Dimethylamino)pyridineHCID 22248400tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate

Product 1

HCID 59455784Tert-butyl 4-fluoro-4-((tosyloxy)methyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-408c6afd80e34afd87aa52eeb787855a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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