1,2-Dichloroethane → tert-butyl N-[6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

HRID 813938Notes

Reaction equation

HRID 813938 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH:9]([CH2:10][CH2:11][CH:12]([CH2:13][NH2:14])[c:15]1[c:16]([F:22])[c:17]([F:21])[cH:18][cH:19][cH:20]1)[C:23](=[O:24])[OH:25])[C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32].[CH2:48]([Cl:49])[CH2:50][Cl:51].[CH3:57][CH2:58][OH:59].[CH:39]([N:40]([CH:41]([CH3:42])[CH3:43])[CH2:44][CH3:45])([CH3:46])[CH3:47].[Cl:33][CH2:34][C:35]([CH3:36])([OH:37])[CH3:38].[Cl:60][CH2:61][Cl:62].[Na+:56].[O-:52][C:53]([OH:54])=[O:55]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH:9]1[CH2:10][CH2:11][CH:12]([c:15]2[c:16]([F:22])[c:17]([F:21])[cH:18][cH:19][cH:20]2)[CH2:13][N:14]([CH2:34][C:35]([CH3:36])([OH:37])[CH3:38])[C:23]1=[O:25])[C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32]

Participants

9

Reactant 8

HCID 111,2-DichloroethaneHCID 702EthanolHCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 684091-Chloro-2-methylpropan-2-olHCID 81531DiisopropylethylamineHCID 222932486-Amino-2-[bis[(2-methylpropan-2-yl)oxycarbonyl]amino]-5-(2,3-difluorophenyl)hexanoic acid

Product 1

HCID 178459286tert-butyl N-[6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

Sources & evidence

ORD record
ord-4f8075fcb3bb414f8154bb5fa6ce7c73
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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