1,2-Dichloroethane → 2-Amino-5-bromo-N-(2-hydroxyethyl)nicotinamide

HRID 815364Notes

Reaction equation

HRID 815364 reaction equation
[CH2:1]([Cl:2])[CH2:3][Cl:4].[CH:31]([N:32]([CH:33]([CH3:34])[CH3:35])[CH2:36][CH3:37])([CH3:38])[CH3:39].[NH2:16][CH2:17][CH2:18][OH:19].[NH2:5][c:6]1[c:7]([C:8](=[O:9])[OH:10])[cH:11][c:12]([Br:15])[cH:13][n:14]1.[O:40]=[CH:41][N:42]([CH3:43])[CH3:44].[OH2:30].[OH2:45].[OH:20][n:21]1[c:22]2[c:23]([cH:24][cH:25][cH:26][cH:27]2)[n:28][n:29]1>>[NH2:5][c:6]1[c:7]([C:8](=[O:10])[NH:16][CH2:17][CH2:18][OH:19])[cH:11][c:12]([Br:15])[cH:13][n:14]1

Participants

8

Reactant 7

HCID 111,2-DichloroethaneHCID 700EthanolamineHCID 962Water2×HCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 7374452-Amino-5-bromonicotinic acid

Product 1

HCID 225937682-Amino-5-bromo-N-(2-hydroxyethyl)nicotinamide

Sources & evidence

ORD record
ord-ddc06f31472a4859ab2065077847893e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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