Cyanide → 4,5-Difluoro-2-(pyridin-2-yloxy)benzonitrile

HRID 816937Notes

Reaction equation

HRID 816937 reaction equation

[Br:1][c:2]1[c:3]([O:4][c:5]2[n:6][cH:7][cH:8][cH:9][cH:10]2)[cH:11][c:12]([F:16])[c:13]([F:15])[cH:14]1.[C-:22]#[N:23].[C-:25]#[N:26].[CH3:17][N:18]([CH3:19])[CH:20]=[O:21].[Zn+2:24]>>[c:2]1([C:17]#[N:18])[c:3]([O:4][c:5]2[n:6][cH:7][cH:8][cH:9][cH:10]2)[cH:11][c:12]([F:16])[c:13]([F:15])[cH:14]1

Participants

5

Reactant 4

HCID 5975Cyanide2×

HCID 6228Dimethylformamide

HCID 32051Zinc(2+)

HCID 685824932-(2-Bromo-4,5-difluorophenoxy)pyridine

Product 1

HCID 685833614,5-Difluoro-2-(pyridin-2-yloxy)benzonitrile

Sources & evidence

ORD record: ord-ddd756d95d5f43a79c3dd9cc1d2c2873
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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