Tetrahydrofuran → Tert-butyl 2-methylazetidine-1-carboxylate

HRID 817035Notes

Reaction equation

HRID 817035 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH2:12][O:13][S:14]([CH3:15])(=[O:16])=[O:17])[CH2:10][CH2:11]1.[CH2:18]([BH-:19]([CH2:20][CH3:21])[CH2:22][CH3:23])[CH3:24].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:26][CH2:27][O:28][C:29](=[O:30])[CH3:31].[Li+:25]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH3:12])[CH2:10][CH2:11]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 2723994TriethylboranuideHCID 72272967Tert-butyl 2-((methanesulfonyloxy)methyl)azetidine-1-carboxylate

Product 1

HCID 21613884Tert-butyl 2-methylazetidine-1-carboxylate

Sources & evidence

ORD record
ord-41d9df16005c47ffb705886f0e030b91
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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