Sodium ion → Tert-butyl 4-(2-methoxyethoxy)piperidin-1-carboxylate

HRID 817293Notes

Reaction equation

HRID 817293 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([OH:14])[CH2:12][CH2:13]1.[CH3:17][O:18][CH2:19][CH2:20][Br:21].[CH3:27][CH2:28][O:29][C:30](=[O:31])[CH3:32].[H-:15].[Na+:16].[O:22]=[CH:23][N:24]([CH3:25])[CH3:26]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][CH2:20][CH2:19][O:18][CH3:17])[CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 809722-Bromoethyl methyl etherHCID 166653HydrideHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 57476927Tert-butyl 4-(2-methoxyethoxy)piperidin-1-carboxylate

Sources & evidence

ORD record
ord-975c7fe2517c447d82cb935bfea813c8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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