Acetate → 5-Carbomethoxy-8-(3-pyridyl)-oct-7-enenitrile

HRID 817874Notes

Reaction equation

HRID 817874 reaction equation
[Br:14][c:15]1[cH:16][n:17][cH:18][cH:19][cH:20]1.[C:50](#[N:51])[CH3:52].[C:53]([O-:54])(=[O:55])[CH3:56].[C:58]([O-:59])(=[O:60])[CH3:61].[CH2:43]([N:44]([CH2:45][CH3:46])[CH2:47][CH3:48])[CH3:49].[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH2:6][CH2:7][CH2:8][C:9]#[N:10])[CH2:11][CH:12]=[CH2:13].[Pd+2:57].[c:21]1([CH3:22])[cH:23][cH:24][cH:25][cH:26][c:27]1[P:28]([c:29]1[cH:30][cH:31][cH:32][cH:33][c:34]1[CH3:35])[c:36]1[cH:37][cH:38][cH:39][cH:40][c:41]1[CH3:42]>>[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH2:6][CH2:7][CH2:8][C:9]#[N:10])[CH2:11][CH:12]=[CH:13][c:15]1[cH:16][n:17][cH:18][cH:19][cH:20]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 6342AcetonitrileHCID 8471TriethylamineHCID 122863-BromopyridineHCID 80271Tri-o-tolylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 149867035-Carbomethoxy-oct-7-enenitrile

Product 1

HCID 543965835-Carbomethoxy-8-(3-pyridyl)-oct-7-enenitrile

Sources & evidence

ORD record
ord-73ad8193f75c482298db1dcdc9d8c03b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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