Chloride → Ethyl(+/-)-4-(4,4,4-trifluoro-1-hydroxybutyl)benzoate

HRID 818370Notes

Reaction equation

HRID 818370 reaction equation
[CH:16]([Mg+:17])([CH3:18])[CH3:19].[Cl-:13].[Cl-:15].[F:20][C:21]([CH2:22][CH2:23][CH:24]=[O:25])([F:26])[F:27].[I:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[O:8][CH2:9][CH3:10])[cH:11][cH:12]1.[Li+:14].[O:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1>>[c:2]1([CH:24]([CH2:23][CH2:22][C:21]([F:20])([F:26])[F:27])[OH:25])[cH:3][cH:4][c:5]([C:6](=[O:7])[O:8][CH2:9][CH3:10])[cH:11][cH:12]1

Participants

7

Reactant 6

HCID 312Chloride2×HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 142891Ethyl 4-iodobenzoateHCID 27770834,4,4-TrifluorobutanalHCID 178461726HCID 178461726, compound

Product 1

HCID 68178660Ethyl(+/-)-4-(4,4,4-trifluoro-1-hydroxybutyl)benzoate

Sources & evidence

ORD record
ord-73513fdcefb84fd5abbab08c6e6947c4
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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