Ammonium → 1-Boc-4-(2-methoxyphenyl)-4-hydroxypiperidine

HRID 818856Notes

Reaction equation

HRID 818856 reaction equation
[Br:1][c:2]1[c:3]([O:8][CH3:9])[cH:4][cH:5][cH:6][cH:7]1.[C:21]([CH3:22])([CH3:23])([CH3:24])[O:25][C:26](=[O:27])[N:28]1[CH2:29][CH2:30][C:31](=[O:34])[CH2:32][CH2:33]1.[CH2:16]([Li:17])[CH2:18][CH2:19][CH3:20].[CH3:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[Cl-:35].[NH4+:36].[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1>>[c:2]1([C:31]2([OH:34])[CH2:30][CH2:29][N:28]([C:26]([O:25][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:27])[CH2:33][CH2:32]2)[c:3]([O:8][CH3:9])[cH:4][cH:5][cH:6][cH:7]1

Participants

8

Reactant 7

HCID 223AmmoniumHCID 312ChlorideHCID 8028TetrahydrofuranHCID 8058HexaneHCID 113582-BromoanisoleHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 226295651-Boc-4-(2-methoxyphenyl)-4-hydroxypiperidine

Sources & evidence

ORD record
ord-e482f80b8f6a44d39b496aa127acec7a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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