Hydrochloric Acid → 4-chloro-5-ethyl-N-(1-formyl-3-methoxypiperidin-4-yl)-1H-imidazole-2-carboxamide

HRID 821321Notes

Reaction equation

HRID 821321 reaction equation
[C:27]([O:28][CH2:29][CH3:30])(=[O:31])[CH3:32].[CH3:43][OH:44].[CH:34]([N:35]([CH:36]([CH3:37])[CH3:38])[CH2:39][CH3:40])([CH3:41])[CH3:42].[Cl:1][c:2]1[n:3][c:4]([C:9](=[O:10])[NH:11][CH:12]2[CH:13]([O:25][CH3:26])[CH2:14][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:16][CH2:17]2)[nH:5][c:6]1[CH2:7][CH3:8].[ClH:33]>>[Cl:1][c:2]1[n:3][c:4]([C:9](=[O:10])[NH:11][CH:12]2[CH:13]([O:25][CH3:26])[CH2:14][N:15]([CH:18]=[O:19])[CH2:16][CH2:17]2)[nH:5][c:6]1[CH2:7][CH3:8]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 68418874tert-butyl 4-[(4-chloro-5-ethyl-1H-imidazole-2-carbonyl)amino]-3-methoxypiperidine-1-carboxylate

Product 1

HCID 723393524-chloro-5-ethyl-N-(1-formyl-3-methoxypiperidin-4-yl)-1H-imidazole-2-carboxamide

Sources & evidence

ORD record
ord-252ddaf72f334d6ab64fdaa7b84a6cb3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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