Dimethylformamide → 6-[5-(4-chlorophenyl)pyridin-2-ylethynyl]-4-methyl-1H-quinolin-2-one

HRID 821618Notes

Reaction equation

HRID 821618 reaction equation
[CH3:16][CH2:17][N:18]([CH2:19][CH3:20])[CH2:21][CH3:22].[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][cH:10][c:11]([C:14]#[CH:15])[n:12][cH:13]2)[cH:6][cH:7]1.[Cu:41][I:42].[I:23][c:24]1[cH:25][c:26]2[c:27]([CH3:35])[cH:28][c:29](=[O:34])[nH:30][c:31]2[cH:32][cH:33]1.[O:36]=[CH:37][N:38]([CH3:39])[CH3:40]>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][cH:10][c:11]([C:14]#[C:15][c:24]3[cH:25][c:26]4[c:27]([CH3:35])[cH:28][c:29](=[O:34])[nH:30][c:31]4[cH:32][cH:33]3)[n:12][cH:13]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 126863636-Iodo-4-methylquinolin-2(1H)-oneHCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridine

Product 1

HCID 690669966-[5-(4-chlorophenyl)pyridin-2-ylethynyl]-4-methyl-1H-quinolin-2-one

Sources & evidence

ORD record
ord-e615f381a1434353a6fb11baceb62ec9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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