Ethyl Acetate → 5-bromo-N-cyclobutylpyrimidin-2-amine

HRID 822413Notes

Reaction equation

HRID 822413 reaction equation

[Br:1][c:2]1[cH:3][n:4][c:5]([Cl:8])[n:6][cH:7]1.[CH3:23][CH2:24][O:25][C:26]([CH3:27])=[O:28].[CH:14]([N:15]([CH2:16][CH3:17])[CH:18]([CH3:19])[CH3:20])([CH3:21])[CH3:22].[CH:9]1([NH2:13])[CH2:10][CH2:11][CH2:12]1>>[Br:1][c:2]1[cH:3][n:4][c:5]([NH:13][CH:9]2[CH2:10][CH2:11][CH2:12]2)[n:6][cH:7]1

Participants

5

Reactant 4

HCID 8857Ethyl Acetate

HCID 75645Cyclobutylamine

HCID 81531Diisopropylethylamine

HCID 6066655-Bromo-2-chloropyrimidine

Product 1

HCID 451586875-bromo-N-cyclobutylpyrimidin-2-amine

Sources & evidence

ORD record: ord-e9c7b853b45244cd85bf0900c5167c3a
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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