1,2-Dichloroethane → 3-(6-amino-3-pyridinyl)-N-methyl-N-(thieno[2,3-b]thiophen-5-ylmethyl)prop-2-enamide

HRID 822633Notes

Reaction equation

HRID 822633 reaction equation
[CH2:1]([Cl:2])[CH2:3][Cl:4].[CH3:17][NH:18][CH2:19][c:20]1[cH:21][c:22]2[c:23]([s:24][cH:25][cH:26]2)[s:27]1.[CH3:39][CH2:40][N:41]([CH2:42][CH3:43])[CH2:44][CH3:45].[NH2:5][c:6]1[cH:7][cH:8][c:9]([CH:12]=[CH:13][C:14](=[O:15])[OH:16])[cH:10][n:11]1.[O:46]=[CH:47][N:48]([CH3:49])[CH3:50].[OH2:38].[OH:28][n:29]1[c:30]2[c:31]([cH:32][cH:33][cH:34][cH:35]2)[n:36][n:37]1>>[NH2:5][c:6]1[cH:7][cH:8][c:9]([CH:12]=[CH:13][C:14](=[O:16])[N:18]([CH3:17])[CH2:19][c:20]2[cH:21][c:22]3[c:23]([s:24][cH:25][cH:26]3)[s:27]2)[cH:10][n:11]1

Participants

8

Reactant 7

HCID 111,2-DichloroethaneHCID 962WaterHCID 6228DimethylformamideHCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 225937092-(Methylaminomethyl)thieno[2,3-b]thiopheneHCID 534008323-(6-Aminopyridin-3-yl)prop-2-enoic acid

Product 1

HCID 667806813-(6-amino-3-pyridinyl)-N-methyl-N-(thieno[2,3-b]thiophen-5-ylmethyl)prop-2-enamide

Sources & evidence

ORD record
ord-279f64ee0fcb41a6a2339ceb0edebd45
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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