反应详情

To a stirred solution of 2-(4-Chloro-phenyl)-3-hydroxy-propionic acid methyl ester (Preparation 243, 500 mg, 2.33 mmol) in THF (7 mL) was added a solution of lithium hydroxide monohydrate (244 mg, 5.82 mmol) in water (2 mL) dropwise at 0° C. and the resulting mixture stirred at room temperature for 1 hour. The reaction mixture was acidified (pH˜3) with 2N hydrochloric acid and extracted with DCM (3×20 mL). The combined organic layers were washed with brine (10 mL), dried (Na2SO4) and evaporated in vacuo to afford the title compound as a white solid in 90% yield, 420 mg.

1. extractionextracted with DCM (3×20 mL)
2. washThe combined organic layers were washed with brine (10 mL)
3. dry with materialdried (Na2SO4)
4. customevaporated in vacuo