Hydrochloric Acid → 4-chloro-2-fluoro-N-methoxy-N-methylbenzamide

HRID 822922Notes

Reaction equation

HRID 822922 reaction equation
[CH3:13][NH:14][O:15][CH3:16].[CH3:17][CH2:18][N:19]=[C:20]=[N:21][CH2:22][CH2:23][CH2:24][N:25]([CH3:26])[CH3:27].[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[Cl:1][c:2]1[cH:3][c:4]([F:11])[c:5]([C:6](=[O:7])[OH:8])[cH:9][cH:10]1.[Cl:35][CH2:36][Cl:37].[ClH:12]>>[Cl:1][c:2]1[cH:3][c:4]([F:11])[c:5]([C:6](=[O:7])[N:14]([CH3:13])[O:15][CH3:16])[cH:9][cH:10]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 8471TriethylamineHCID 14232N,O-DimethylhydroxylamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 991524-Chloro-2-fluorobenzoic acid

Product 1

HCID 222258304-chloro-2-fluoro-N-methoxy-N-methylbenzamide

Sources & evidence

ORD record
ord-552f5768b127461d9a8d0c03c8b57b8b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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