Water → 4-[2-amino-7'-(2-cyclopropylethynyl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-3'-yl]-2-methylbut-3-yn-2-ol

HRID 823092Notes

Reaction equation

HRID 823092 reaction equation
[C:55](#[CH:56])[CH:57]1[CH2:58][CH2:59]1.[CH:48]([NH:49][CH:50]([CH3:51])[CH3:52])([CH3:53])[CH3:54].[Cu:61][I:62].[F:1][C:2]([F:3])([S:4]([O:5][c:17]1[cH:18][c:19]2[c:34]([cH:35][cH:36]1)[O:33][c:22]1[c:21]([cH:26][c:25]([C:27]#[C:28][C:29]([CH3:30])([CH3:31])[OH:32])[cH:24][n:23]1)[C:20]21[N:37]=[C:38]([NH2:41])[O:39][CH2:40]1)(=[O:6])=[O:7])[C:8]([F:9])([F:10])[C:11]([F:12])([F:13])[C:14]([F:15])([F:16])[F:42].[O:43]=[CH:44][N:45]([CH3:46])[CH3:47].[OH2:60]>>[c:17]1([C:56]#[C:55][CH:57]2[CH2:58][CH2:59]2)[cH:18][c:19]2[c:34]([cH:35][cH:36]1)[O:33][c:22]1[c:21]([cH:26][c:25]([C:27]#[C:28][C:29]([CH3:30])([CH3:31])[OH:32])[cH:24][n:23]1)[C:20]21[N:37]=[C:38]([NH2:41])[O:39][CH2:40]1

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 7912DiisopropylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 138823CyclopropylacetyleneHCID 87323715HCID 87323715, compound

Product 1

HCID 672414814-[2-amino-7'-(2-cyclopropylethynyl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-3'-yl]-2-methylbut-3-yn-2-ol

Sources & evidence

ORD record
ord-5c40c9c1f9af49b7b7e62c86becf08b1
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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