Picolinic acid → Pyridine-2-carboxylic acid 4-hydroxymethyl-benzylamide

HRID 824111Notes

Reaction equation

HRID 824111 reaction equation
[CH:30]([N:31]([CH2:32][CH3:33])[CH:34]([CH3:35])[CH3:36])([CH3:37])[CH3:38].[NH2:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][OH:8])[cH:9][cH:10]1.[O:39]=[CH:40][N:41]([CH3:42])[CH3:43].[OH:11][C:12](=[O:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][n:19]1.[OH:20][n:21]1[c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]2[n:28][n:29]1>>[NH:1]([CH2:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][OH:8])[cH:9][cH:10]1)[C:12](=[O:11])[c:14]1[cH:15][cH:16][cH:17][cH:18][n:19]1

Participants

6

Reactant 5

HCID 1018Picolinic acidHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 6496943[4-(Aminomethyl)phenyl]methanol

Product 1

HCID 22601292Pyridine-2-carboxylic acid 4-hydroxymethyl-benzylamide

Sources & evidence

ORD record
ord-ddd170bb0ff14e888a3374b5768839dd
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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