Hydrochloric Acid → t-Butyl 1-benzyloxycarbonyl-4-cyclohexylmethylaminocarbonylpiperidin-4-ylcarbamate

HRID 824496Notes

Reaction equation

HRID 824496 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH2:12][CH2:13][C:14]([C:17](=[O:18])[OH:19])([NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:15][CH2:16]1.[CH2:29]([N:30]=[C:31]=[N:32][CH2:33][CH2:34][CH2:35][N:36]([CH3:37])[CH3:38])[CH3:39].[CH3:49][N:50]([CH3:51])[CH:52]=[O:53].[CH:40]1([CH2:46][NH2:47])[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45]1.[ClH:28].[OH2:48]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH2:12][CH2:13][C:14]([C:17](=[O:19])[NH:47][CH2:46][CH:40]2[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45]2)([NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:15][CH2:16]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 962WaterHCID 6228DimethylformamideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 76688CyclohexanemethylamineHCID 231027164-n-Boc-amino-1-cbz-isonipecotic acid

Product 1

HCID 67038112t-Butyl 1-benzyloxycarbonyl-4-cyclohexylmethylaminocarbonylpiperidin-4-ylcarbamate

Sources & evidence

ORD record
ord-d0de27a51ba04123acdb1a33d7230083
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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