Chloride → 6-chloro-N,N-diethyl-4-o-tolyl-nicotinamide

HRID 825148Notes

Reaction equation

HRID 825148 reaction equation
[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH3:24][OH:25].[Cl-:1].[Cl:10][c:11]1[n:12][cH:13][c:14]([C:15](=[O:16])[N:17]([CH2:18][CH3:19])[CH2:20][CH3:21])[cH:22][cH:23]1.[Cl:26][C:27]1=[C:38]([Cl:39])[C:36](=[O:37])[C:33]([C:34]#[N:35])=[C:30]([C:31]#[N:32])[C:28]1=[O:29].[c:2]1([CH3:9])[c:3]([Mg+:8])[cH:4][cH:5][cH:6][cH:7]1>>[c:2]1([CH3:9])[c:3](-[c:22]2[c:14]([C:15](=[O:16])[N:17]([CH2:18][CH3:19])[CH2:20][CH3:21])[cH:13][n:12][c:11]([Cl:10])[cH:23]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

7

Reactant 6

HCID 312ChlorideHCID 887MethanolHCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 8028TetrahydrofuranHCID 5878136-Chloro-N,N-diethylnicotinamideHCID 178424302HCID 178424302, compound

Product 1

HCID 121673216-chloro-N,N-diethyl-4-o-tolyl-nicotinamide

Sources & evidence

ORD record
ord-cf42b41069f24916aef85ec2c21c050c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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