Hydrochloric Acid → Tert-butyl 7-fluoro-2-(4-fluorophenyl)-5-(2-methyl-5-(1-phenylcyclopropylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carbonyl(methyl)carbamate
Reaction equation
[C:21]([CH3:22])([CH3:23])([CH3:24])[O:25][C:26](=[O:27])[N:28]([C:29](=[O:30])[c:31]1[c:32](-[c:51]2[cH:52][cH:53][c:54]([F:57])[cH:55][cH:56]2)[n:33][n:34]2[c:35]1[cH:36][c:37](-[c:41]1[cH:42][c:43]([C:44](=[O:45])[OH:46])[cH:47][cH:48][c:49]1[CH3:50])[cH:38][c:39]2[F:40])[CH3:58].[CH:12]([N:13]([CH:14]([CH3:15])[CH3:16])[CH2:17][CH3:18])([CH3:19])[CH3:20].[ClH:1].[O:83]=[CH:84][N:85]([CH3:86])[CH3:87].[P-:59]([F:60])([F:61])([F:62])([F:63])([F:64])[F:65].[c:2]1([C:8]2([NH2:11])[CH2:9][CH2:10]2)[cH:3][cH:4][cH:5][cH:6][cH:7]1.[n:66]1([O:67][C:68]([N:69]([CH3:70])[CH3:71])=[N+:72]([CH3:73])[CH3:74])[c:75]2[n:76][cH:77][cH:78][cH:79][c:80]2[n:81][n:82]1>>[c:2]1([C:8]2([NH:11][C:44]([c:43]3[cH:42][c:41](-[c:37]4[cH:36][c:35]5[c:31]([C:29]([N:28]([C:26]([O:25][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:27])[CH3:58])=[O:30])[c:32](-[c:51]6[cH:52][cH:53][c:54]([F:57])[cH:55][cH:56]6)[n:33][n:34]5[c:39]([F:40])[cH:38]4)[c:49]([CH3:50])[cH:48][cH:47]3)=[O:45])[CH2:9][CH2:10]2)[cH:3][cH:4][cH:5][cH:6][cH:7]1Participants
8
Reactant 7
HCID 313Hydrochloric Acid
HCID 6228Dimethylformamide
HCID 9886Hexafluorophosphate
HCID 81531Diisopropylethylamine
HCID 1945491-Phenyl-cyclopropylamine
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium
HCID 592338333-(3-(Tert-butoxycarbonyl(methyl)carbamoyl)-7-fluoro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-5-yl)-4-methylbenzoic acidProduct 1
Sources & evidence
- ORD record
- ord-d5cf5a6766584c848e4afa3b4817169e
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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