Chloride → 5-((4-Chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)indolin-2-one

HRID 825264Notes

Reaction equation

HRID 825264 reaction equation
[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[Cl-:31].[Cl-:33].[F:1][C:2]([c:3]1[c:4]([Cl:10])[n:5][c:6]([Cl:9])[n:7][cH:8]1)([F:11])[F:12].[NH2:13][c:14]1[cH:15][c:16]2[c:20]([cH:21][cH:22]1)[NH:19][C:18](=[O:23])[CH2:17]2.[Zn+2:32]>>[F:1][C:2]([c:3]1[c:4]([Cl:10])[n:5][c:6]([NH:13][c:14]2[cH:15][c:16]3[c:20]([cH:21][cH:22]2)[NH:19][C:18](=[O:23])[CH2:17]3)[n:7][cH:8]1)([F:11])[F:12]

Participants

6

Reactant 5

HCID 312Chloride2×HCID 8471TriethylamineHCID 32051Zinc(2+)HCID 27732135-Amino-2-oxindoleHCID 27827742,4-Dichloro-5-(trifluoromethyl)pyrimidine

Product 1

HCID 219231045-((4-Chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)indolin-2-one

Sources & evidence

ORD record
ord-ed46afa0a6a347c6afc663bc9aebe384
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…