Tetrahydrofuran → N-[5-(4-fluoro-phenyl)-isoxazol-3-yl]-malonamic acid ethyl ester

HRID 826213Notes

Reaction equation

HRID 826213 reaction equation
[CH2:23]([CH3:24])[O:25][C:26]([CH2:27][C:28](=[O:29])[OH:30])=[O:31].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:37][CH2:38][O:39][C:40](=[O:41])[CH3:42].[CH:1]([N:2]=[C:3]=[N:4][CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9].[F:10][c:11]1[cH:12][cH:13][c:14](-[c:17]2[cH:18][c:19]([NH2:22])[n:20][o:21]2)[cH:15][cH:16]1>>[F:10][c:11]1[cH:12][cH:13][c:14](-[c:17]2[cH:18][c:19]([NH:22][C:28]([CH2:27][C:26]([O:25][CH2:23][CH3:24])=[O:31])=[O:29])[n:20][o:21]2)[cH:15][cH:16]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 12734DiisopropylcarbodiimideHCID 70615Monoethyl malonateHCID 132004245-(4-Fluorophenyl)-1,2-oxazol-3-amine

Product 1

HCID 57875802N-[5-(4-fluoro-phenyl)-isoxazol-3-yl]-malonamic acid ethyl ester

Sources & evidence

ORD record
ord-aee013b480c94f25a6a67350deaaae00
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…