Dichloromethane → tert-Butyl 4-(dimethylcarbamoyl)piperazine-1-carboxylate

HRID 827279Notes

Reaction equation

HRID 827279 reaction equation
[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1.[CH3:14][CH2:15][N:16]([CH2:17][CH3:18])[CH2:19][CH3:20].[CH3:21][N:22]([C:23](=[O:24])[Cl:25])[CH3:26].[Cl:32][CH2:33][Cl:34].[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][N:11]([C:23]([N:22]([CH3:21])[CH3:26])=[O:24])[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 6598Dimethylcarbamoyl ChlorideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 22665738tert-Butyl 4-(dimethylcarbamoyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-530c237e3c67496891b144b7aab003f9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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