Bicarbonate Ion → 5-[4-(2-Azepan-1-yl-ethoxy)-phenyl]-10-fluoro-5H-6-oxa-chrysen-2-ol

HRID 828517Notes

Reaction equation

HRID 828517 reaction equation
[C:46](=[O:47])([OH:48])[O-:49].[CH2:38]([BH-:39]([CH2:40][CH3:41])[CH2:42][CH3:43])[CH3:44].[CH2:65]1[O:66][CH2:67][CH2:68][CH2:69]1.[CH:51]([OH:52])([CH3:53])[CH3:54].[CH:55]([Cl:56])([Cl:57])[Cl:58].[Li+:45].[N:1]1([CH2:8][CH2:9][O:10][c:11]2[cH:12][cH:13][c:14]([C:17](=[O:18])[c:19]3[c:20](-[c:30]4[c:31]([F:37])[cH:32][cH:33][cH:34][c:35]4[F:36])[cH:21][cH:22][c:23]4[cH:24][c:25]([OH:29])[cH:26][cH:27][c:28]34)[cH:15][cH:16]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1.[Na+:50].[O:59]1[CH2:60][CH2:61][O:62][CH2:63][CH2:64]1>>[N:1]1([CH2:8][CH2:9][O:10][c:11]2[cH:12][cH:13][c:14]([CH:17]3[O:18][c:31]4[c:30]([c:35]([F:36])[cH:34][cH:33][cH:32]4)-[c:20]4[c:19]3[c:28]3[c:23]([cH:22][cH:21]4)[cH:24][c:25]([OH:29])[cH:26][cH:27]3)[cH:15][cH:16]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

10

Reactant 9

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 3776IsopropanolHCID 6212ChloroformHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 312751,4-DioxaneHCID 2723994TriethylboranuideHCID 67004735[4-(2-Azepan-1-yl-ethoxy)-phenyl]-[2-(2,6-difluoro-phenyl)-6-hydroxy-naphthalen-1-yl]-methanone

Product 1

HCID 114658405-[4-(2-Azepan-1-yl-ethoxy)-phenyl]-10-fluoro-5H-6-oxa-chrysen-2-ol

Sources & evidence

ORD record
ord-87092d10bd6e478ba7273a2314a0f4b7
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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