Tetrahydrofuran → 2-(3,5-Difluorophenyl)-5-pentylpyrimidine

HRID 828757Notes

Reaction equation

HRID 828757 reaction equation
[Cl:11][c:12]1[n:13][cH:14][c:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[cH:16][n:17]1.[F:2][c:3]1[cH:4][c:5]([Br:10])[cH:6][c:7]([F:9])[cH:8]1.[Mg:1].[Ni:28]([Cl:29])[Cl:30].[O:23]1[CH2:24][CH2:25][CH2:26][CH2:27]1>>[F:2][c:3]1[cH:4][c:5](-[c:12]2[n:13][cH:14][c:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[cH:16][n:17]2)[cH:6][c:7]([F:9])[cH:8]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 24385Nickel DichlorideHCID 1363131-Bromo-3,5-difluorobenzeneHCID 5462224MagnesiumHCID 167565262-Chloro-5-pentylpyrimidine

Product 1

HCID 183482702-(3,5-Difluorophenyl)-5-pentylpyrimidine

Sources & evidence

ORD record
ord-0b74fc697a5045fe8809de14d8d96d5e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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