Chloroform → tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate

HRID 831228Notes

Reaction equation

[Al+3:2].[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[CH:31]([Cl:32])([Cl:33])[Cl:34].[F:7][C:8]1([C:21](=[O:22])[O:23][CH2:24][CH3:25])[CH2:9][CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]1.[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3]>>[F:7][C:8]1([CH2:21][OH:22])[CH2:9][CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]1