Chloride → 6-Bromo-8-chloro-4-isopropyl-7-methoxy-2,2-dimethyl-2H-chromene

HRID 832767Notes

Reaction equation

HRID 832767 reaction equation
[Br:6][c:7]1[cH:8][c:9]2[c:14]([c:15]([Cl:19])[c:16]1[O:17][CH3:18])[O:13][C:12]([CH3:20])([CH3:21])[CH2:11][C:10]2=[O:22].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:23][N:24]1[CH2:25][CH2:26][CH2:27][N:28]([CH3:29])[C:30]1=[O:31].[CH:2]([CH3:3])([CH3:4])[Mg+:5].[Cl-:1]>>[CH:2]([CH3:3])([CH3:4])[C:10]1=[CH:11][C:12]([CH3:20])([CH3:21])[O:13][c:14]2[c:9]1[cH:8][c:7]([Br:6])[c:16]([O:17][CH3:18])[c:15]2[Cl:19]

Participants

6

Reactant 5

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-HCID 224910326-Bromo-8-chloro-7-methoxy-2,2-dimethyl-chroman-4-oneHCID 178461726HCID 178461726, compound

Product 1

HCID 224908856-Bromo-8-chloro-4-isopropyl-7-methoxy-2,2-dimethyl-2H-chromene

Sources & evidence

ORD record
ord-34b84962ff494d0a895254d5d1d3685c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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