Dimethylformamide → 6-bromo-3-hydroxymethyl-2-(4-methanesulfonylbenzyl)-4-phenyl-2H-isoquinolin-1-one

HRID 832805Notes

Reaction equation

HRID 832805 reaction equation
[Br:6][c:7]1[cH:8][c:9]2[c:10](-[c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)[c:11]([C:29](=[O:30])[OH:31])[n:12]([CH2:18][c:19]3[cH:20][cH:21][c:22]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:23][cH:24]3)[c:13](=[O:17])[c:14]2[cH:15][cH:16]1.[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[Cl:38][C:39]([C:40]([Cl:41])=[O:42])=[O:43].[O:1]=[CH:2][N:3]([CH3:4])[CH3:5]>>[Br:6][c:7]1[cH:8][c:9]2[c:10](-[c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)[c:11]([CH2:29][OH:30])[n:12]([CH2:18][c:19]3[cH:20][cH:21][c:22]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:23][cH:24]3)[c:13](=[O:17])[c:14]2[cH:15][cH:16]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 230609586-Bromo-2-(4-methanesulfonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid

Product 1

HCID 230608406-bromo-3-hydroxymethyl-2-(4-methanesulfonylbenzyl)-4-phenyl-2H-isoquinolin-1-one

Sources & evidence

ORD record
ord-797f32c927dc44fb80499fbe41a4c785
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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