Acetonitrile → 2-(4'-Fluorophenyl)-4-[4'-(3-dimethylamino-2-propyn-1-yl)phenyl]thiazole

HRID 834625Notes

Reaction equation

HRID 834625 reaction equation
[CH2:45]([NH:46][CH2:47][CH3:48])[CH3:49].[CH3:39][N:40]([CH2:41][C:42]#[CH:43])[CH3:44].[CH3:50][C:51]#[N:52].[Cu:56][I:57].[F:20][c:21]1[cH:22][cH:23][c:24](-[c:27]2[s:28][cH:29][c:30](-[c:32]3[cH:33][cH:34][c:35]([Br:38])[cH:36][cH:37]3)[n:31]2)[cH:25][cH:26]1.[Pd:53]([Cl:54])[Cl:55].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[F:20][c:21]1[cH:22][cH:23][c:24](-[c:27]2[s:28][cH:29][c:30](-[c:32]3[cH:33][cH:34][c:35]([CH2:43][C:42]#[C:41][N:40]([CH3:39])[CH3:44])[cH:36][cH:37]3)[n:31]2)[cH:25][cH:26]1

Participants

8

Reactant 7

HCID 6342AcetonitrileHCID 8021DiethylamineHCID 11776TriphenylphosphineHCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 81643N,N-DimethylpropargylamineHCID 111749984-(4-Bromo-phenyl)-2-(4-fluoro-phenyl)-thiazole

Product 1

HCID 226110582-(4'-Fluorophenyl)-4-[4'-(3-dimethylamino-2-propyn-1-yl)phenyl]thiazole

Sources & evidence

ORD record
ord-c76b68f10c924bd190b52402cc5fa694
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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